FB2025_01 , released February 20, 2025
Allele: Dmel\ea14
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General Information
Symbol
Dmel\ea14
Species
D. melanogaster
Name
FlyBase ID
FBal0003468
Feature type
allele
Associated gene
Dmel\ea
Associated Insertion(s)
Carried in Construct
Also Known As
ea818
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Point mutation in the catalytic site.

(Lemaitre et al., 1996)

Amino acid replacement: C324Y.

(Jin and Anderson, 1990)

Nucleotide substitution: G1174A.

(Jin and Anderson, 1990)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:15,330,153..15,330,153 [+]
Nucleotide change:

G15330153A

Reported nucleotide change:

G1174A

Amino acid change:

C324Y | ea-PA; C193Y | ea-PB

Reported amino acid change:

C324Y

(Jin and Anderson, 1990)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Bacterially challenged mutants exhibit a wild type Drs response. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate.

      (Lemaitre et al., 1996)

      Embryos weakly ventralized at 18[o]C and strongly dorsalized at 29[o]C.

      (Jin and Anderson, 1990)

      Temperature-sensitive allele.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ea14
      ea818
      (Levashina et al., 1998, Lemaitre et al., 1996, Jin and Anderson, 1990, Tearle and Nusslein-Volhard, 1987)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)