FB2025_01 , released February 20, 2025
Allele: Dmel\Polr1D1
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General Information
Symbol
Dmel\Polr1D1
Species
D. melanogaster
Name
FlyBase ID
FBal0008786
Feature type
allele
Associated gene
Dmel\Polr1D
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
gamma ray
Progenitor genotype
Cytology
Description

Amino acid replacement: G30R.

(Palumbo et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,133,282..19,133,282 [-]
Nucleotide change:

G19133282A

Reported nucleotide change:

G?A

Amino acid change:

G30R | Polr1D-PA; G41R | Polr1D-PC; G57R | Polr1D-PD

Reported amino acid change:

G30R

(Palumbo et al., 2022)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Treacher Collins syndrome 2
      CEC
      (Palumbo et al., 2022)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygous l(2)37Cg1/Df(2L)TW130 animals do not survive to the third larval instar stage.

      (McCrady and Tolin, 1994)

      Lethality occurs after 7 days in the second larval instar stage.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Wright.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Cg1
      (Wright, 1996)
      Polr1D1
      (Palumbo et al., 2022)
      l(2)37Cg1
      l(2)7414
      Name Synonyms
      Secondary FlyBase IDs
        References (4)