FB2025_01 , released February 20, 2025
Allele: Dmel\wblM88
Open Close
General Information
Symbol
Dmel\wblM88
Species
D. melanogaster
Name
FlyBase ID
FBal0033171
Feature type
allele
Associated gene
Dmel\wbl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Konsolaki and Schupbach, 1998)
Progenitor genotype
Cytology
Description

7bp deletion between bases 455 and 461. This destroys the reading frame after amino acid 130, and generates a termination codon after another 36 amino acids.

(Konsolaki and Schupbach, 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:19,250,419..19,250,425 [+]
Comment:

7 bp deletion which destroys the reading frame after amino acid 130, and generates a termination codon after another 36 amino acids.

(Konsolaki and Schupbach, 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos derived from homozygous females are strongly dorsalised. Homozygous adults show reduced viability, the lethal phase being between the second and third larval instar stages. Transheterozygotes with wblRP, wblM46, wblT6 or wblE4 also have reduced viability, and embryos derived from these transheterozygous females are dorsalised and fail to hatch. wblM88/wblAR51 transheterozygotes have reduced viability, and approximately 99% of embryos laid by wblM88/wblAR51 females hatch.

      (Konsolaki and Schupbach, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Double mutant combinations with eaD3 are strongly dorsalized.

      (Chasan et al., 1992)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      wblM88
      windM88
      (Sen et al., 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)