FB2025_01 , released February 20, 2025
Allele: Dmel\BicDr10
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General Information
Symbol
Dmel\BicDr10
Species
D. melanogaster
Name
FlyBase ID
FBal0038140
Feature type
allele
Associated gene
Dmel\BicD
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Ran et al., 1994)
Mutagen
ethyl methanesulfonate
(Ran et al., 1994)
Progenitor genotype
BicDr
(Ran et al., 1994)
Cytology
Description

Amino acid replacement: K653term.

(Ran et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:17,462,528..17,462,528 [-]
Nucleotide change:

A17462528T

Amino acid change:

K653term | BicD-PA; K653term | BicD-PB; K653term | BicD-PC; K653term | BicD-PD

Reported amino acid change:

K653term

Comment:

This is in addition to the A40V substitution of the parental BicDr chromosome. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Ran et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Fertile over BicD1, and viable but sterile over BicDr or BicDR26. Lethality is complete at 29oC, but some adults escape at 18oC. Survival can be markedly improved by raising the flies on apple juice-agar medium supplemented with live yeast. Resulting adults are uncoordinated and generally die within a couple of days. Ovaries contain only egg chambers with 16 polyploid nuclei and no oocyte. Germ line clones give rise to 16-nurse cell chambers with no oocyte. Reorganization of ring canals does not occur. The largest ring canal does not move to the posterior end of the cluster and is found in apparently random positions in the posterior half of the egg chamber.

      (Ran et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      BicD9
      (Suter, 2015.8.17)
      BicDr10
      (Suter, 2015.8.17)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)