FB2025_01 , released February 20, 2025
Allele: Dmel\Arr2S366A
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General Information
Symbol
Dmel\Arr2S366A
Species
D. melanogaster
Name
FlyBase ID
FBal0098946
Feature type
allele
Associated gene
Dmel\Arr2
Associated Insertion(s)
Carried in Construct
P{Arr2S366A}
Key Links
Transgenic product class
missense_variant
(Alloway and Dolph, 1999)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Alloway and Dolph, 1999)
Mutagen
in vitro construct
(Alloway and Dolph, 1999)
Progenitor genotype
Carried in construct
P{Arr2S366A}
Cytology
Description

A mutated Arr2 coding region carrying the S366A amino acid replacement is expressed under the control of approximately 2kb of endogenous promoter sequence.

(Alloway and Dolph, 1999)
Allele components
Component
Use(s)
Regulatory region(s)
Arr2
Encoded product / tool
Arr2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dissociated ommatidia from flies carrying Arr2S366A in a Arr25 background show a minor flash-response deactivation defect in the presence of Ca[2+], a five-fold slower flash-response in solution with or without Ca[2+], and a 10-fold slower response deactivation in Ca[2+]-free solution.

      (Liu et al., 2008)

      Electroretinograms of flies carrying Arr2S366A in an Arr25 background have marked defects in inactivation kinetics.

      (Alloway and Dolph, 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Arr2S366A
      (Liu et al., 2008)
      S366A
      (Alloway and Dolph, 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)