FB2025_01 , released February 20, 2025
Allele: Dmel\Cog1e02840
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General Information
Symbol
Dmel\Cog1e02840
Species
D. melanogaster
Name
FlyBase ID
FBal0161359
Feature type
allele
Associated gene
Dmel\Cog1
Associated Insertion(s)
PBac{RB}Cog1e02840
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{RB}Cog1e02840
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{RB}
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  metal metabolism disorder
      modeled by ATP7UAS.cBa
      (Hartwig et al., 2021, Comstra et al., 2017)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cog1e02840 heterozygotes display increased cumulative synapse branch length but normal bouton density in neuromuscular junctions in third instar larvae as compared to controls.

      (Comstra et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased bouton density and reduced synaptic brach length of neuromuscular junctions in third instar larvae expressing ATP7Scer\UAS.cBa under the control of Scer\GAL4elav-C155 is suppressed by combination with a single copy of Cog1e02840 - the phenotype resembles that of Cog1e02840 heterozygotes alone: the bouton density is comparable to wild-type but the cumulative branch length is increased.

      (Comstra et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG4848e02840
      Cog1e02840
      (Hartwig et al., 2021)
      cog1e02840
      (Comstra et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)