FB2025_01 , released February 20, 2025
Allele: Dmel\Top3β37
Open Close
General Information
Symbol
Dmel\Top3β37
Species
D. melanogaster
Name
FlyBase ID
FBal0195412
Feature type
allele
Associated gene
Dmel\Top3β
Associated Insertion(s)
P{?EP}Top3β37
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Wu et al., 2006)
Mutagen
P-element activity
(Wu et al., 2006)
Progenitor genotype
P{EP}Top3βEP1432
(Wu et al., 2006)
Associated Insertion(s)
P{?EP}Top3β37
Cytology
Description

Imprecise excision of the P{EP} element, resulting in a 712bp deletion of the first exon and most of the second exon, corresponding to nucleotide 36 upstream to 672 downstream of the translation start site. A 2.3kb fragment of the P{EP} element is left behind.

(Wu et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Top3β37 mutants show no pronounced fertility defects and their lifespan is normal.

      (Wu et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Top3β37
      (Lee et al., 2018)
      top3β37
      (Wu et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)