FB2025_01 , released February 20, 2025
Allele: Dmel\Sema5cBG01245
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General Information
Symbol
Dmel\Sema5cBG01245
Species
D. melanogaster
Name
FlyBase ID
FBal0195600
Feature type
allele
Associated gene
Dmel\Sema5c
Associated Insertion(s)
P{GT1}Sema5cBG01245
Carried in Construct
Also Known As
BG01245
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GT1}Sema5cBG01245
    Cytology
    Description

    P{GT1} insertion 197bp upstream of the first exon of Sema-5c.

    (Rollmann et al., 2007)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GT1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Sema-5cBG01245 mutant flies (males and females pooled) sleep on average 108.6 minutes longer per 24 hours than wild type flies. No significant difference is seen between the sexes.

        (Harbison and Sehgal, 2008)

        Sema-5cBG01245 flies show a reduced avoidance response to benzaldehyde compared to control flies in an olfactory assay.

        Approximately 10% of Sema-5cBG01245 adults show defects in the α-lobes of the mushroom body. There is also a significant reduction in the surface area of the ellipsoid body compared to controls.

        (Rollmann et al., 2007)

        Mutants show an abnormal olfactory avoidance response to 0.3% benzaldehyde.

        (Sambandan et al., 2006)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Complements

        Sema5cE77

        (Rollmann et al., 2007)
        Fails to complement

        Sema5cE215

        (Rollmann et al., 2007)
        Rescued by

        Sema5cBG01245 is rescued by Scer\GAL4Sema5c-BG01245/Sema5cUAS.cBa

        (Rollmann et al., 2007)
        Comments

        Sema-5cE77 complements the olfactory avoidance defects of Sema-5cBG01245.

        Sema-5cE215 complements the olfactory avoidance defects of Sema-5cBG01245.

        (Rollmann et al., 2007)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        BG01245
        (Sambandan et al., 2006)
        BG01245BG01245
        Sema-5cBG01245
        (Shin and Diantonio, 2011)
        Sema5cBG01245
        Name Synonyms
        Secondary FlyBase IDs
          References (4)