FB2025_01 , released February 20, 2025
Allele: Dmel\Arr2R393A
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General Information
Symbol
Dmel\Arr2R393A
Species
D. melanogaster
Name
FlyBase ID
FBal0246062
Feature type
allele
Associated gene
Dmel\Arr2
Associated Insertion(s)
Carried in Construct
P{Arr2.R393A}
Key Links
Transgenic product class
missense_variant
(Orem et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Orem et al., 2006)
Mutagen
in vitro construct
(Orem et al., 2006)
Progenitor genotype
Carried in construct
P{Arr2.R393A}
Cytology
Description

Amino acid replacement: R393A.

(Orem et al., 2006)

An Arr2 genomic fragment containing the endogenous promoter and all intron and exon sequences, and carrying a point mutation in the C terminus (R393A).

(Orem et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
Arr2
Encoded product / tool
Arr2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  retinal disease
      modeled by norpAEE5
      (Orem et al., 2006)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In an electroretinogram of dark-reared, newly eclosed Arr2R393A mutant flies, photoreceptor receptor cells behave similarly to wild-type.

      Eyes from Arr2R393A mutant flies exposed to 5 days of constant light show some retinal degeneration, but not rapid degeneration as observed in Arr25 mutants.

      Eyes from Arr2R393A mutant flies exposed to a 12-hour light/dark cycle from 30 days show moderate retinal degeneration characterised by large intracellular holes and darkened cytoplasm.

      (Orem et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Arr2R393A is a suppressor of retina | conditional | somatic clone phenotype of norpAEE5

      (Orem et al., 2006)

      Arr2R393A is a suppressor of eye photoreceptor cell | conditional | somatic clone phenotype of norpAEE5

      (Orem et al., 2006)

      Arr2R393A is a suppressor of rhabdomere | conditional | somatic clone phenotype of norpAEE5

      (Orem et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Arr2R393A
      Name Synonyms
      Secondary FlyBase IDs
        References (1)