Allele Dmel\fd3F¹

General Information
Symbol	Dmel\fd3F¹	Species	D. melanogaster
Name		FlyBase ID	FBal0256940
Feature type	allele	Associated gene	Dmel\fd3F

Allele class	loss of function allele
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Newton et al., 2012)
Mutagen	P-element activity (Cachero et al., 2011)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	fd3F^EP1198 (Cachero et al., 2011)
Nature of the lesion	Statement Reference Deletion of 1.4kb that removes approximately 400bp of the 3' end of the fd3F open reading frame. (Newton et al., 2012) Imprecise excision of P{EP}fd3F[EP1198] deletes the 3' end of the fd3F transcription unit. (Cachero et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	auditory perception defective \| adult stage (Newton et al., 2012) gravitaxis defective \| recessive (Newton et al., 2012) locomotor behavior defective (Cachero et al., 2011) neuroanatomy defective \| adult stage (Newton et al., 2012) neuroanatomy defective \| embryonic stage (Newton et al., 2012) neurophysiology defective \| adult stage (Newton et al., 2012)
Phenotype Manifest In
	Johnston organ neuron (Newton et al., 2012) scolopidial cilium (Newton et al., 2012) scolopidial neuron \| embryonic stage (Newton et al., 2012)
Detailed Description
	Statement Reference Homozygous adults perform very poorly in a climbing assay. Mutant flies show no sound-evoked compound action potentials in the projections of Johnston's organ neurons in the antennal nerve. Analysis of the mechanical response of the antennal sound receiver to tones of different intensities indicates that chordotonal organ cilium motility is lost. The chordotonal cilium of the Johnston's organ lacks the dynein outer and inner arms in the proximal region. Cilia of embryonic chordotonal neurons show abnormal dilation. (Newton et al., 2012) fd3F[1] mutant larvae and adult flies exhibit locomotion defects. Ch neurons are mostly specified normally in fd3F[1] mutants, with little gross structural defects observed in these mutants. (Cachero et al., 2011)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	fd3F¹ (Cachero et al., 2011, Newton et al., 2012)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Newton et al., 2012, Dev. Cell 22(6): 1221--1233 Forkhead Transcription Factor Fd3F Cooperates with Rfx to Regulate a Gene Expression Program for Mechanosensory Cilia Specialization. [FBrf0218629] Cachero et al., 2011, PLoS Biol. 9(1): e1000568 The gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons. [FBrf0212891]

Allele Dmel\fd3F1

Allele Dmel\fd3F¹