FB2025_01 , released February 20, 2025
Allele: Dmel\X11L80
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General Information
Symbol
Dmel\X11L80
Species
D. melanogaster
Name
FlyBase ID
FBal0304609
Feature type
allele
Associated gene
Dmel\X11L
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gross et al., 2013)
Progenitor genotype
Cytology
Description

Imprecise excision of P{EPg}HP10026 from the 5'UTR of X11L generates a X11L deletion mutant.

(Gross et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      X11L80 mutants are viable and adults are wild-type in appearance.

      X11L80 mutant mushroom body lobes exhibit mislocalised multiple axonal membrane proteins and lobe structural defects. The dorsal lobe is aberrantly formed, causing it to be severely truncated. In addition, the medial lobe appears frayed and misshapen, indicating abnormal axon development.

      (Gross et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      X11L80 has mushroom body vertical lobe phenotype, enhanceable by AP-2α06694

      (Gross et al., 2013)

      X11L80 has mushroom body medial lobe phenotype, enhanceable by AP-2α06694

      (Gross et al., 2013)
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Pan-neuronal silencing of X11LβdsRNA.Scer\UAS under the control of Scer\GAL4elav.PU, in a X11L80 homozygous background results in early to mid-third instar larval lethality.

      A AP-2α06694 homozygous mutant background enhances the dendritic mislocalisation of axonal membrane proteins and structural defects in the mushroom body of X11L80 mutants.

      (Gross et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\APBA2Scer\UAS.cHa under the control of Scer\GAL4elav.PU, partially rescues the axonal membrane protein mislocalisation and structural defects seen in the mushroom body of X11L80 mutants.

      (Gross et al., 2013)
      Complementation and Rescue Data
      Partially rescued by

      X11L80 is partially rescued by X11LUAS.cGb/Scer\GAL4elav.PU

      (Gross et al., 2013)
      Comments

      Expression of X11LScer\UAS.cGa under the control of Scer\GAL4elav.PU, partially rescues the axonal membrane protein mislocalisation and structural defects seen in the mushroom body of X11L80 mutants.

      (Gross et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      X11L80
      X11Lα80
      (Gross et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)