FB2025_01 , released February 20, 2025
Allele: Hsap\VPS35UAS.cWa.Tag:HA
Open Close
General Information
Symbol
Hsap\VPS35UAS.cWa.Tag:HA
Species
H. sapiens
Name
FlyBase ID
FBal0321385
Feature type
allele
Associated gene
Hsap\VPS35
Associated Insertion(s)
Carried in Construct
P{UAS-hVPS35.WT.HA}
Key Links
Transgenic product class
wild_type
(Wang et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Wang et al., 2014)
Mutagen
in vitro construct
(Wang et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-hVPS35.WT.HA}
Cytology
Description

UASt regulatory sequences drive expression of wild-type Hsap\VPS35. The protein is tagged at the C-terminal end with Tag:HA.

(Wang et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\VPS35
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease
      CEA
      (Wang et al., 2014)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\VPS35Scer\UAS.cWa.T:Ivir\HA1 under the control of Scer\GAL4Ddc.PU results in age-progressive loss of dopaminergic neurons in the PPL1 cluster (but not in PAL, PM1/2, PPM3 and PPL2 clusters) in the adult brain and significantly reduces climbing ability of the adult flies compared to age-matched controls (at 20 and 40 but not at 60 days post-eclosion).

      (Wang et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\VPS35Scer\UAS.cWa.T:Ivir\HA1
      Hsap\VPS35UAS.cWa.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)