FB2025_01 , released February 20, 2025
Allele: Dmel\perS828A.Tag:HA,Tag:polyHis
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General Information
Symbol
Dmel\perS828A.Tag:HA,Tag:polyHis
Species
D. melanogaster
Name
FlyBase ID
FBal0324262
Feature type
allele
Associated gene
Dmel\per
Associated Insertion(s)
Carried in Construct
P{per13.2.S828A.HAHis}
Key Links
Transgenic product class
missense_variant
(Yildirim et al., 2015)
polypeptide_post_translational_processing_variant
(Yildirim et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Yildirim et al., 2015)
polypeptide_post_translational_processing_variant
(Yildirim et al., 2015)
Mutagen
in vitro construct
(Yildirim et al., 2015)
Progenitor genotype
Carried in construct
P{per13.2.S828A.HAHis}
Cytology
Description

A 13.2kb genomic fragment containing the per gene, into which the S828A mutation has been introduced (to block phosphorylation at this residue). The open reading frame is tagged at the C-terminal end with Tag:HA and multiple histidine residues (10xHis).

(Yildirim et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
per
Encoded product / tool
per
Tagged with
Tag:HA
Tag:polyHis
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult per01 flies expressing perS828A.T:Ivir\HA1,T:Zzzz\His6 (rescue flies) display robust circadian activity rhythm in constant dark (preceded by an 12:12 light:dark entrainment period) with an avg period of 22.6 hr, significantly shorter than wild-type.

      (Yildirim et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      perS828A.T:Ivir\HA1,T:Zzzz\His6
      perS828A.Tag:HA,Tag:polyHis
      Name Synonyms
      Secondary FlyBase IDs
        References (1)