FB2025_01 , released February 20, 2025
Allele: Dmel\Herc4C6.3
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General Information
Symbol
Dmel\Herc4C6.3
Species
D. melanogaster
Name
FlyBase ID
FBal0327467
Feature type
allele
Associated gene
Dmel\Herc4
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Aerne et al., 2015)
Mutagen
CRISPR/Cas9
(Aerne et al., 2015)
Progenitor genotype
Cytology
Description

A one base-pair deletion at codon position C92 (cysteine 92) that induces a frame-shift resulting in the production of a 30aa peptide (followed by 24aa of out-of-frame sequence), which lacks most of the Herc4 protein.

(Aerne et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:1,314,168..1,314,168 [+]
Comment:

Deletion of one base (C) at position 92 relative to the ATG causes a frameshift at amino acid 31 and early translation termination after the addition of 24 novel amino acids.

(Aerne et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Herc4C6.3 homozygous adults do not display significant changes in wing area, as compared to controls.

      (Aerne et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Herc4C6.3/Herc4C6.3 is a non-suppressor of wing | adult stage phenotype of Scer\GAL4rn.PU, savUAS.WT

      (Aerne et al., 2015)

      Herc4C6.3/Herc4C6.3 is a non-suppressor of wing | adult stage phenotype of Scer\GAL4rn.PU, savS413A.UAS

      (Aerne et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Herc4C6.3
      herc4C6.3
      (Aerne et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)