FB2025_01 , released February 20, 2025
Allele: Dmel\RhoGEF3RNAi.UAS
Open Close
General Information
Symbol
Dmel\RhoGEF3RNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0337799
Feature type
allele
Associated gene
Dmel\RhoGEF3
Associated Insertion(s)
Carried in Construct
M{UAS-RhoGEF3.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Nakamura et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Nakamura et al., 2017)
Mutagen
in vitro construct
(Nakamura et al., 2017)
Progenitor genotype
Carried in construct
M{UAS-RhoGEF3.RNAi}
Cytology
Description

UAS regulatory and P\T promoter sequences (derived from the pWALIUM22 vector) drive expression of an RNAi line that targets RhoGEF3.

(Nakamura et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
RhoGEF3
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Wounded embryos expressing RhoGEF3dsRNA.shRNA.Scer\UAS.P\T under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 show wound overexpansion, delayed actin accumulation around the wound edge and delayed repair, as compared to wounded control embryos.

      (Nakamura et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      RhoGEF3RNAi(2)
      (Nakamura et al., 2017)
      RhoGEF3RNAi.UAS
      RhoGEF3dsRNA.shRNA.Scer\UAS.P\T
      RhoGEF3dsRNA.shRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)