FB2025_01 , released February 20, 2025
Allele: Dmel\hiroF1
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General Information
Symbol
Dmel\hiroF1
Species
D. melanogaster
Name
FlyBase ID
FBal0338598
Feature type
allele
Associated gene
Dmel\hiro
Associated Insertion(s)
TI{TI}hiroF1
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Huang et al., 2018)
Mutagen
CRISPR/Cas9
(Huang et al., 2018)
Progenitor genotype
Associated Insertion(s)
TI{TI}hiroF1
Cytology
Description

The majority of the hiro coding region is replaced with a dsRed marker.

(Huang et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3L:686,041..687,368 [-]
Comment:

The majority of the hiro coding region has been deleted and replaced with a dsRed marker.

(Brown and Ryoo, 2018.6.27)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  retinitis pigmentosa
      modeled by ninaEG69D
      (Huang et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      hiroF1 homozygotes and hiroF1/Df(3L)5 transheterozygotes are viable and do not exhibit any obvious external morphology defects. hiroF1 homozygotes also do not exhibit any significant retinal degeneration compared to controls.

      (Huang et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      hiroF1/hiroF1 is an enhancer of retina | adult stage | progressive phenotype of ninaEG69D

      (Huang et al., 2018)

      hiroF1/hiroF1 is an enhancer of ommatidium | adult stage | progressive phenotype of ninaEG69D

      (Huang et al., 2018)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      hiroF1 homozygosity exacerbates the retinal degeneration observed in ninaEG69D heterozygotes.

      (Huang et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      hiroF1
      (Huang et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)