FB2025_01 , released February 20, 2025
Allele: Dmel\Mocs2AKK101263
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General Information
Symbol
Dmel\Mocs2AKK101263
Species
D. melanogaster
Name
FlyBase ID
FBal0338646
Feature type
allele
Associated gene
Dmel\Mocs2A
Associated Insertion(s)
Carried in Construct
P{KK101263}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Marelja et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Marelja et al., 2018)
Mutagen
in vitro construct
(Marelja et al., 2018)
Progenitor genotype
Carried in construct
P{KK101263}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat that is predicted to target the products of both Mocs2A and Mocs2B (that share a dicistronic transcript) for RNAi-mediated degradation.

(Marelja et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK101263
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Third instar larvae expressing Mocs2AKK101263 under the control of Scer\GAL4GMR83E12 display crawling defects, namely a significant increase in head bending and a significantly decreased peristalsis efficacy, but no significant changes in peristalsis frequency, as compared to controls.

      (Otto et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mocs2AKK101263
      Name Synonyms
      Secondary FlyBase IDs
        References (3)