FB2025_01 , released February 20, 2025
Allele: Dmel\midS0021
Open Close
General Information
Symbol
Dmel\midS0021
Species
D. melanogaster
Name
FlyBase ID
FBal0343463
Feature type
allele
Associated gene
Dmel\mid
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Schwarz et al., 2018)
Progenitor genotype
Cytology
Description

Splice acceptor site mutation in intron 3; truncation in T-box domain.

(Schwarz et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:5,465,893..5,465,893 [+]
Nucleotide change:

G5465893A

Reported nucleotide change:

G4255A

Comment:

Nucleotide substitution: AG changed to AA in the splice acceptor.

(Schwarz et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      midS0021 mutant embryos show cardioblast (CB) patterning defects and a lower generic CBs:ostial CBs ratio than the typical 4:2 ratio.

      (Schwarz et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Chromosome also carries a second site mutation in bib.

      (Schwarz et al., 2018)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      midS0021
      (Schwarz et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)