FB2025_01 , released February 20, 2025
Allele: Dmel\SS4550
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General Information
Symbol
Dmel\SS4550
Species
D. melanogaster
Name
FlyBase ID
FBal0343469
Feature type
allele
Associated gene
Dmel\S
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Schwarz et al., 2018)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q142term.

(Schwarz et al., 2018)

Truncation in intracellular domain, loss of transmembrane and lumenal domain.

(Schwarz et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:1,061,723..1,061,723 [-]
Nucleotide change:

C1061723T

Reported nucleotide change:

C16093T

Amino acid change:

Q142term | S-PA; Q142term | S-PB

Reported amino acid change:

Q142term

(Schwarz et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      SS4550 mutant embryos show cardioblast (CB) patterning defects and a lower generic CBs:ostial CBs ratio than the typical 4:2 ratio.

      Stage 10, 11 and 12 SS4550 mutant embryos show increased apoptosis (TUNEL assay) in several tissues but not in Tin-positive cardiogenic mesoderm, as compared to controls.

      (Schwarz et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      SS4550
      (Schwarz et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)