FB2025_01 , released February 20, 2025
Allele: Dmel\PRL-14
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General Information
Symbol
Dmel\PRL-14
Species
D. melanogaster
Name
FlyBase ID
FBal0349221
Feature type
allele
Associated gene
Dmel\PRL-1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Urwyler et al., 2019)
Mutagen
CRISPR/Cas9
(Urwyler et al., 2019)
Progenitor genotype
Cytology
Description

A small deletion results in a frame-shift and premature termination codon within PRL-1 (I33*).

(Urwyler et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:16,248,864..16,248,867 [-]
Comment:

Four base deletion leads to a frameshift and early translation termination after the addition of three novel amino acids.

(Urwyler et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      PRL-12/PRL-14 posterior dorsocentral bristle neurons do not show striking differences in synapse ultrastructure, as compared to controls.

      PRL-14 homozygous show a significantly smaller ventral nerve cord, as compared to controls.

      Posterior dorsocentral bristle neurons of individuals that are both PRL-12/PRL-14 transheterozygous and express PRL-1UAS.cPa under the control of Scer\GAL4pnr-MD237 do not show significant projection defects (terminal arbor territory or number of synapses/ Syt1-positive puncta) in the contralateral branch, as compared to controls.

      (Urwyler et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PRL-14
      prl-14
      (Urwyler et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)