FB2025_01 , released February 20, 2025
Allele: Hsap\SNCAQUAS.Tag:FLAG.T2A-GFP
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General Information
Symbol
Hsap\SNCAQUAS.Tag:FLAG.T2A-GFP
Species
H. sapiens
Name
FlyBase ID
FBal0406734
Feature type
allele
Associated gene
Hsap\SNCA
Associated Insertion(s)
Carried in Construct
P{QUAS-hSNCA-FLAG-T2A-GFP}
Key Links
Transgenic product class
wild_type
(Bankapalli et al., 2024)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Bankapalli et al., 2024)
Mutagen
in vitro construct
(Bankapalli et al., 2024)
Progenitor genotype
Carried in construct
P{QUAS-hSNCA-FLAG-T2A-GFP}
Cytology
Description

QUAS sequences regulate expression of a transcript that encodes two open reading frames separated by a T2A sequence (to ensure separate translation of each ORF). The first ORF encodes Hsap\SNCA tagged with Tag:FLAG. The second ORF encodes GFP.

(Bankapalli et al., 2024)
Allele components
Component
Use(s)
Regulatory region(s)
QUAS
Encoded product / tool
Hsap\SNCA
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease
      CEA
      (Bankapalli et al., 2024)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  Parkinson's disease
      is exacerbated by sggUAS.cBa
      (Bankapalli et al., 2024)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsap\SNCAQUAS.Tag:FLAG.T2A-GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)