FB2025_01 , released February 20, 2025
Gene Group: FERRITINS
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General Information
Name
FERRITINS
Species
D. melanogaster
Symbol
FER
FlyBase ID
FBgg0000649
Date last reviewed
2017-02-17
Number of members
3
Description
Description
Ferritins (FER) function as main iron storage proteins and regulate iron homeostasis. Cytoplasmic ferritin is a heteropolymer of heavy and light chain subunits encoded by Fer1HCH and Fer2LCH, respectively. Mitochondrial ferritin exists as a homopolymer of Fer3HCH proteins. Heavy chain homologs (Fer1HCH and Fer3HCH) have ferroxidase activity, essential for the incorporation of iron into the ferritin shell. Light chain homologs (Fer2LCH) play a role in the nucleation of the ferritin iron cores. (Adapted from FBrf0190848 and PMID:20230873).
Notes on Group
Source Material
The FERRITINS Gene Group has been compiled using the following publication(s): Tang and Zhou, 2013, Tiklová et al., 2010, Dunkov and Georgieva, 2006, Missirlis et al., 2006, and Dunkov and Georgieva, 1999 .
Key Gene Ontology (GO) terms
Molecular Function
iron ion binding
Biological Process
intracellular iron ion homeostasis
Cellular Component
ferritin complex
Related Gene Groups
Members (3)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Fer1HCH
Ferritin 1 heavy chain homologue
FerHCH, ferritin, Fer1, ferritin heavy chain, l(3)00451
(Tang and Zhou, 2013, Tiklová et al., 2010, Dunkov and Georgieva, 2006, Missirlis et al., 2006, Dunkov and Georgieva, 1999)
Fer2LCH
Ferritin 2 light chain homologue
l(3)neo63, l(3)neo60, l(3)00035, FerLCH
(Tang and Zhou, 2013, Tiklová et al., 2010, Dunkov and Georgieva, 2006, Missirlis et al., 2006, Dunkov and Georgieva, 1999)
Fer3HCH
Ferritin 3 heavy chain homologue
(Tang and Zhou, 2013, Dunkov and Georgieva, 2006, Missirlis et al., 2006)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
FER
FERRITINS
Secondary FlyBase ID(s)
References (6)