Alpha 1,3-fucosyltransferases catalyze the transfer of a fucose residue from the donor substrate, GDP-fucose, to an acceptor oligosaccharide, glycoprotein or glycolipid in an α-1,3-linkage. They are type II transmembrane Golgi-anchored proteins containing an N-terminal cytoplasmic tail, a transmembrane domain, and an extended stem region followed by a large globular C-terminal catalytic domain facing the Golgi lumen. (Adapted from PMID:16973733.)