FB2025_01 , released February 20, 2025
Gene Group: MD-2-RELATED LIPID-RECOGNITION PROTEINS
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General Information
Name
MD-2-RELATED LIPID-RECOGNITION PROTEINS
Species
D. melanogaster
Symbol
ML
FlyBase ID
FBgg0001653
Date last reviewed
2024-05-30
Number of members
8
Description
Description
Myeloid differentiation factor-2-related lipid-recognition (ML) domain-containing proteins are a broadly classed as lipid-binding proteins and have been implicated in processes such as lipid metabolism and innate immunity. (Adapted from FBrf0218672.)
Notes on Group

In Drosophila, Npc2a and Npc2b are thought have functions similar to vertebrate Niemann-Pick C2 (NPC2) in lysosomal sterol trafficking (FBrf0218672 and FBrf0201424).

Source Material
The MD-2-RELATED LIPID-RECOGNITION PROTEINS Gene Group has been compiled using the following publication(s): Shi et al., 2012 and Huang et al., 2007 .
Key Gene Ontology (GO) terms
Molecular Function
lipid binding
Biological Process
Cellular Component
Related Gene Groups
Other related group(s)
SLC65 FAMILY OF NPC-TYPE CHOLESTEROL TRANSPORTERS
Members (8)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Npc2a
Niemann-Pick type C-2a
NPC2, Niemann-Pick Type C-2
(Shi et al., 2012, Huang et al., 2007)
Npc2b
Niemann-Pick type C-2b
(Shi et al., 2012, Huang et al., 2007)
Npc2c
Niemann-Pick type C-2c
(Shi et al., 2012, Huang et al., 2007)
Npc2d
Niemann-Pick type C-2d
(Shi et al., 2012, Huang et al., 2007)
Npc2e
Niemann-Pick type C-2e
(Shi et al., 2012, Huang et al., 2007)
Npc2f
Niemann-Pick type C-2f
(Shi et al., 2012, Huang et al., 2007)
Npc2g
Niemann-Pick type C-2g
(Shi et al., 2012, Huang et al., 2007)
Npc2h
Niemann-Pick type C-2h
(Shi et al., 2012, Huang et al., 2007)
External Data
Synonyms and Secondary IDs
Synonym(s)
ML
ML proteins
Myeloid differentiation factor-2-related lipid-recognition domain-containing proteins
NPC2 proteins
Niemann-Pick disease type C2 proteins
Npc2-like
NPC2
MD-2-RELATED LIPID-RECOGNITION PROTEINS
Secondary FlyBase ID(s)
References (3)