FB2025_01 , released February 20, 2025
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
lark, Ae2
FlyBase ID
FBig0000106754
Interaction Network
Interactions Browser links
lark network
Ae2 network
esyN Network Diagram
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Protein
RNA
Selected Interactor(s)
Common Interactor(s)
Reported Interactions
FBrf0233521-4.PD.PCR
Reference
Swain et al., 2016
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
lark 

Lark

bait

His tag

lark 
Ae2 

CG8177

prey
Ae2 
Ae2 
Ae2 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
lark 
RRM1-RRM2-ZnF
sufficient binding region
aa 1-211

coordinates relative to lark-PA

Ae2 
region 1
sufficient binding region
GGAACUGUAAAUCAUUACGUUCGGAAACGUGCUGCUGCUCGGACGGAAACGCAGAAACUG

"CG8177-1" construct

Ae2 
region 7
sufficient binding region
CCCUCUGCUUUAUCGUCUGUUGUUUUUAUCGACGCGUUCGCUCCCGCGUUCUUUCUCCUU

"CG8177-7" construct

Ae2 
region 8
sufficient binding region
CGCGUUCUUUCUCCUUCUCCAGCCAGCGCGAGUGUGUGUGUGUGUGUCUCG

"CG8177-8" construct

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey produced and labeled by in vitro transcription.

(Swain et al., 2016)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)