FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term midline glial cell ID (Ontology) FBbt:00001315 (Fly Anatomy)
Definition Glial cell that is derived from the mesectoderm (Ito et al., 1995). It is located on or close to the midline of the ventral nerve cord (Ito et al., 1995). At embryonic stage 11, these cells form two populations, an anterior cluster of around 6 cells per neuromere and a posterior cluster of around 4 cells per neuromere (Wheeler et al., 2006). Three of the anterior cells persist into the larval stage, with the rest of the midline glia being lost by apoptosis (Wheeler et al., 2009). In the larva, these cells ensheath the anterior and posterior axon commissures (Ito et al., 1995).[ FlyBase:FBrf0076141 FlyBase:FBrf0082171 FlyBase:FBrf0098773 FlyBase:FBrf0180108 FlyBase:FBrf0195284 FlyBase:FBrf0207445 FlyBase:FBrf0214261 ]
Also Known As "AMG" ; "anterior midline glia" ; "MGA" (for all, see Synonyms field below)
Comment Ito et al. (1995) states that there are generally three or four midline glial cells per neuromere, but occasionally there are more than four. The thoracic neuromeres are more likely than the abdominal neuromeres to have more. Midline glia are repo (FBgn0011701) negative and are eliminated by apoptosis during the pupal stage.
Links to External Ontologies
VFB:FBbt_00001315
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  PHENOTYPE_MANIFEST_IN     132
Insertions (FBti)  EXPRESSION_STAGE_TISSUE_POSITION      50
Insertions (FBti)  PHENOTYPE_MANIFEST_IN      11
Constructs (FBtp)  PHENOTYPE_MANIFEST_IN      43
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Alleles Genes Images Insertions Constructs
 midline glial cell (all annotations which use CV term, excluding "NOT" statements)     135     83      3     60     57
     midline glial cell | dorsal closure stage       1       --       --       --       --
     midline glial cell | ectopic      18       --       --       2      8
     midline glial cell | embryonic stage       1       --       --       --       --
     midline glial cell | embryonic stage 13       2       --       --       1       --
     midline glial cell | embryonic stage 13 | increased number       4       --       --       --       4
     midline glial cell | embryonic stage 14       2       --       --       --       2
     midline glial cell | embryonic stage 16       5       --       --       1       --
     midline glial cell | embryonic stage 16 | increased number      12       --       --       --      10
     midline glial cell | embryonic stage | increased number       1       --       --       --       --
     midline glial cell | heat sensitive       1       --       --       --       1
     midline glial cell | increased number       3       --       --       --       --
     midline glial cell | larval stage       2       --       --       1       --
     midline glial cell | maternal effect | increased number       1       --       --       --       --
Spanning Tree (Parents/Children)
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ectodermal derivative
 |__mesectodermal derivative__
somatic cell                  |
 |__glial cell________________|
                              midline glial cell  410 rec.
                               |__embryonic anterior midline glial cell
                               |__embryonic posterior midline glial cell 25 rec.
                               |__larval dorsal midline glial cell
                               |__larval ventral midline glial cell 84 rec.
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Is a glial cell
mesectodermal derivative
Develops from embryonic midline glioblast
Part of
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Synonyms
Secondary IDs
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VFB:FBbt_00001315