Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Term | mushroom body dorsal paired medial cell | ID (Ontology) | FBbt:00005780 (Fly Anatomy) |
| Definition | A serotonergic (Lee et al., 2011) and GABAergic (Haynes et al., 2015) mushroom body intrinsic neuron of the adult whose large cell body (~12um) is located in the dorsal posterior medial area of the brain, ventromedial to the calyx (Waddell et al., 2000; Tanaka et al., 2008). There is one of these cells per hemisphere and it innervates the entire ipsilateral mushroom body lobe system and distal pedunculus (Tanaka et al., 2008; Li et al., 2020). Its cell body fiber bifurcates in the superior neuropils, with one branch entering the tip of the gamma lobe and the other branching to enter at the base of the alpha lobe/lateral gamma lobe and the tip of the alpha' lobe (Waddell et al., 2000; Tanaka et al., 2008). It is synapsed to and by Kenyon cells throughout the mushroom body lobes and also has outputs to dopaminergic mushroom body input neurons (DANs) and mushroom body output neurons (MBONs) (Takemura et al., 2017; Li et al., 2020). This neuron is also electrically connected to the mushroom body anterior paired lateral cell (Wu et al., 2011). It is involved in sleep and memory consolidation (Haynes et al., 2015). It is a secondary neuron (Truman et al., 2023) that develops from the DM3 neuroblast (Ito et al., 2013).[ FlyBase:FBrf0132261 FlyBase:FBrf0205263 FlyBase:FBrf0213725 FlyBase:FBrf0213804 FlyBase:FBrf0214737 FlyBase:FBrf0221438 FlyBase:FBrf0227396 FlyBase:FBrf0236382 FlyBase:FBrf0248215 FlyBase:FBrf0255928 ] | ||
| Also Known As | "dorsal paired medial cell" ; "DPM" ; "MB-DPM" | ||
| Comment | Pre-synaptic terminals were identified using the pre-synaptic marker Bruchpilot in DPM neurons genetically labelled with the c316-GAL4 driver (FBti0017056) (Pitman et al., 2011). Electrical connectivity was inferred using dye coupling (Wu et al., 2011). Neurotransmitter release was assessed by immunostaining to two different serotonergic antibodies: 5HT and Ddc (Lee et al., 2011). Detectable by its large amn-expressing cell body (Waddell et al., 2000). | ||
| Links to External Ontologies | |||
| VFB:FBbt_00005780 | |||
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neuron |__secondary neuron________________ interneuron | |__mushroom body intrinsic neuron__| |__adult interneuron_______________| serotonergic neuron | |__adult serotonergic neuron_______| GABAergic neuron | |__adult GABAergic neuron__________| adult neuron | |__adult GABAergic neuron__________| DPMpm2 lineage neuron | |__adult DM3 lineage neuron________| adult aminergic neuron | |__adult serotonergic neuron_______| adult CNS neuron | |__adult DM3 lineage neuron________| |__adult interneuron_______________| mushroom body dorsal paired medial cell 40 rec. |
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mushroom body intrinsic neuron secondary neuron adult serotonergic neuron adult DM3 lineage neuron adult interneuron adult GABAergic neuron |
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| Part of | adult brain | ||
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FlyBrain_NDB:10445 VFB:FBbt_00005780 |
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