FlyBase Allele Report: Dmel\αTub67C[1]

General Information

Symbol

Dmel\αTub67C¹

Species

D. melanogaster

Name

FlyBase ID

FBal0000008

Feature type

allele

Associated gene

Dmel\αTub67C

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Matthews et al., 1993)

Mutagen

ethyl methanesulfonate

(Matthews et al., 1993)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

male germline stem cell | decreased number

(Tao et al., 2021)

male germline stem cell | decreased number (with αTub67C³)

(Tao et al., 2021)

male germline stem cell | decreased number (with αTub67C^RX2.1)

(Tao et al., 2021)

male germline stem cell | decreased number | somatic clone

(Tao et al., 2021)

spindle & oocyte (with αTub67C²)

(Jang et al., 2005)

spindle | ectopic (with αTub67C^unspecified)

(Mathe et al., 1998)

spindle | embryonic stage (with αTub67C^unspecified)

(Mathe et al., 1998)

Detailed Description

Statement

Reference

αTub67C¹/αTub67C² females show severe defects in bipolar spindle formation in the oocyte.

(Jang et al., 2005)

X/FM7a; αTub67C¹/+ females show elevated levels of X chromosome nondisjunction.

(Matthies et al., 1999)

Eggs derived from females transheterozygous for αTub67C^unspecified and αTub67C¹ have abnormal gonomeric spindles. Abnormal ectopic cleavage spindles form, the abnormality becoming more severe with time.

(Mathe et al., 1998)

αTub67C³/αTub67C¹ females produce patroclinous daughters at low frequency; these females arise by fusion of haploid cleavage nuclei or failure of newly replicated haploid chromosomes to segregate.

(Komma and Endow, 1995)

No eggs from hemizygous females hatch. Many are apparently unfertilized, though insemination occurs. Paternal genotype has no effect on viability of progeny. Majority of eggs had 3 or fewer nuclei. This allele also shows a dominant reduction in female fertility.

(Matthews et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

αTub67C¹ has female sterile | dominant phenotype, suppressible by swa^unspecified

(Pokrywka et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

αTub67C¹ has phenotype, enhanceable by ncd^D

(Komma and Endow, 1997)

Suppressed by

Statement

Reference

αTub67C¹ has phenotype, suppressible by nod^unspecified

(Matthies et al., 1999)

Enhancer of

Statement

Reference

αTub67C¹ is an enhancer of phenotype of ncd^D

(Komma and Endow, 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Does not interact with alleles of sub.

(Giunta et al., 2002)

ncd^D/ncd^D enhances the production of exceptional androgenetic females by αTub67C¹ heterozygotes. αTub67C¹ dominantly enhances the frequencies of nondisjunction and zygotic loss of the X chromosome in ncd^D/ncd^D flies.

(Komma and Endow, 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Rescued by

αTub67C¹ is rescued by αTub67C^nanos.PT

(Tao et al., 2021)

αTub67C¹/αTub67C^RX2.1 is rescued by αTub67C^+t7.3

(Tao et al., 2021)

αTub67C³/αTub67C¹ is rescued by αTub67C^+t7.3

(Tao et al., 2021)

αTub67C¹ is rescued by αTub67C^+t7

(Matthews et al., 1993)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

1750

αTub67C¹ kni^ri-1 e¹/TM3, Sb¹

Kyoto

106485

αTub67C¹ kni^ri-1 e¹/TM6C, Tb¹ Sb¹

Notes on Origin

Discoverer

K. Matthews.

Comments

Based on average degree of development of eggs of the hemizygous mutant genotype the alleles can be ranked, from most to least severe, in the order αTub67C² < αTub67C⁴ < αTub67C¹ < αTub67C³. Based on the semidominant phenotypes the rank order is αTub67C³ < αTub67C¹ = αTub67C² = αTub67C⁴.

(Matthews et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

alphaTub67C¹

(Christensen et al., 2007.10.29, Christensen et al., 2007.10.29)

α-Tub67C¹

(Jang et al., 2005)

αTub67C¹

(Hasan et al., 2024, Tao et al., 2021, Fahmy et al., 2014, Christensen et al., 2008.9.3, Christensen et al., 2008.12.28)

αtub67C¹

(Matthies et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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