FB2025_01 , released February 20, 2025
Allele: Dmel\dl5
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General Information
Symbol
Dmel\dl5
Species
D. melanogaster
Name
FlyBase ID
FBal0002647
Feature type
allele
Associated gene
Dmel\dl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Lemaitre et al., 1995, Isoda et al., 1992, Steward and Nusslein-Volhard, 1986)

loss of function allele

(Bergmann et al., 1996)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
X ray
(Steward and Nusslein-Volhard, 1986)
Progenitor genotype
Cytology
Description

Val to Met substitution at amino acid 188, within the amino terminal half.

(Isoda et al., 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:17,442,287..17,442,287 [-]
Nucleotide change:

G17442287A

Amino acid change:

V188M | dl-PA; V188M | dl-PB; V188M | dl-PC; V188M | dl-PD; V188M | dl-PE; V188M | dl-PF

Reported amino acid change:

V188M

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Isoda et al., 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When in trans with Df(2L)TW119 the transgene P{Dipt2.2-lacZ} is not induced.

      (Lemaitre et al., 1995)

      Strong dorsalization: loss of ventral epidermis.

      (Isoda et al., 1992)

      Weak dorsal phenotype.

      (Steward and Nusslein-Volhard, 1986)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      dl5 has embryo phenotype, suppressible by Tcas\dlUAS.cCa/Scer\GAL4VP16.mat.αTub67C

      (Chen et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Tcas\dlScer\UAS.cCa under the control of Scer\GAL4mat.alphaTub67C.T:Hsim\VP16 partially suppresses dl5/Df(2L)TW119. One copy of the transgene leads to differentiation of dorsolateral structures (e.g. filzkorper); two copies promote, in addition, the formation of ventrolateral structures (e.g. ventral epidermis).

      (Chen et al., 2000)
      Complementation and Rescue Data
      Rescued by

      Df(2L)TW119/dl5 is rescued by dlUAS.cCa/Scer\GAL4VP16.mat.αTub67C

      (Chen et al., 2000)
      Comments

      Expression of dlScer\UAS.cCa under the control of Scer\GAL4mat.alphaTub67C.T:Hsim\VP16 completely suppresses the dl5/Df(2L)TW119 phenotype, sometimes even to the point of ventralisation.

      (Chen et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dl5
      (Chen et al., 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)