FB2025_01 , released February 20, 2025
Allele: Dmel\Col4a1DTS-L11
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General Information
Symbol
Dmel\Col4a1DTS-L11
Species
D. melanogaster
Name
FlyBase ID
FBal0008291
Feature type
allele
Associated gene
Dmel\Col4a1
Associated Insertion(s)
Carried in Construct
Also Known As
DTS11
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
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        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Cg25CDTS-L11 heterozygotes show dominant semi-lethality at 29[o]C but are viable at 20[o]C. Homozygotes raised at 20[o]C are lethal.

        (Kelemen-Valkony et al., 2012)

        Heterozygotes form rigid mitochondrial (MC) membranes and microsomal (MC) membranes at the restrictive temperature, 29oC. Normal ordering state of the membrane can be achieved by a temperature shift up, but not by a shift down to the permissive temperature. l(2)25Ca7 is less able to adjust MC and MS fatty acid composition in response to the growth temperature.

        (Szidonya et al., 1990)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Suppressor of
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (6)
        Reported As
        Symbol Synonym
        Cg25CDTS-L11
        Col4a1DTS-L11
        DTS-L11
        (Kelemen-Valkony et al., 2012)
        DTS11
        (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
        l(2)10DTS
        (Szidonya et al., 1990)
        l(2)25Ca7
        Name Synonyms
        Secondary FlyBase IDs
          References (5)