FB2025_01 , released February 20, 2025
Allele: Dmel\tld15
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General Information
Symbol
Dmel\tld15
Species
D. melanogaster
Name
FlyBase ID
FBal0016886
Feature type
allele
Associated gene
Dmel\tld
Associated Insertion(s)
Carried in Construct
Also Known As
tld10F
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Raftery et al., 1995, Childs and O'Connor, 1994, Arora and Nusslein-Volhard, 1992, Ferguson and Anderson, 1992)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G1393A.

(Childs and O'Connor, 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:24,751,483..24,751,483 [+]
Nucleotide change:

G24751483A

Reported nucleotide change:

G1393A

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported nucleotide substitution due to different start site used by authors. Mutation is in splice donor in intron 4

(Childs and O'Connor, 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      No significant enhancement of the dpp mutant phenotype.

      (Raftery et al., 1995)

      Moderate ventralised phenotype. No amnioserosa, reduction of dorsal cuticle and increase in the width of the ventral setal belts in each segment: results in defective movements of the germ band. Dorsal cell fates are deleted and ventrolateral mitotic domains are expanded.

      (Arora and Nusslein-Volhard, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Resulting in an intron 4 splice mutant.

      (Childs and O'Connor, 1994)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      tldMBT

      (Riede, 2001)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Strong tld allele.

      (Childs and O'Connor, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      10F102
      (Riede, 2001)
      tld10F102
      (Childs and O'Connor, 1994)
      tld10F
      (Arora and Nusslein-Volhard, 1992, Ferguson and Anderson, 1992, Tearle and Nusslein-Volhard, 1987)
      tld15
      Name Synonyms
      Secondary FlyBase IDs
        References (7)