Allele Dmel\vg^U

General Information
Symbol	Dmel\vg^U	Species	D. melanogaster
Name	Ultra	FlyBase ID	FBal0017907
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\vg

Allele class	gain of function
Mutagen	γ ray
Nature of the Allele
Allele class	gain of function (Williams et al., 1990)
Mutagen	γ ray
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Fusion between mam and vg (second intron); proximal break ar +4 kb; '+' values to right (distal); 0 coordinate assigned to insert position of vg²¹; Williams, Atkin and Bell (1990) Inversion breakpoint within vg. This results in a fusion between mam and the distal part of the vg gene. The mam sequences fused to vg are intronic and the breakpoint in mam is at -27 (coordinates are as in FBrf0048222). (Williams et al., 1990)
Assay mode
Caused by aberration	In(2R)vg^U (Williams et al., 1990, Simmonds et al., 1997, Silber et al., 1997)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Bownes and Roberts, 1981, Rabinow and Birchler, 1990) visible (Simmonds et al., 1997) visible \| dominant (Bownes and Roberts, 1981, Williams et al., 1990, Williams and Bell, 1988, Rabinow and Birchler, 1990)
Phenotype Manifest In
	wing (Bownes and Roberts, 1981, Williams et al., 1990, Simmonds et al., 1997, Rabinow and Birchler, 1990) haltere (Williams et al., 1990)
Detailed Description
	Statement Reference Hemizygous vg^U/vg^- survivors (50%) show extreme mutant phenotype. Partial revertant of vg^U reported by Silber and Lemeunier (1981). homozygous lethal; dominant; vg^U/+ has much reduced wings and halteres; vg^U/vg¹ has tiny wings, no halteres Heterozygotes have a vestigial wing phenotype. The wings lack margin structures. vg^W/vg^U flies are lethal and fail to emerge as adults. Lethal in combination with Df(2R)vg-C. Viable in combination with Df(2R)vg-B, Df(2R)vg-D and Df(2R)vg-S. vg^U/Df(2R)vg-B and vg^U/Df(2R)vg-D flies are sterile. (Bownes and Roberts, 1981) One dose removes entire wing margin. (Williams and Bell, 1988) Adults exhibit no wings. (Rabinow and Birchler, 1990) Heterozygotes have a severe reduction of wing and haltere. vg^U/Df(2R)vg-B flies resemble the vg null phenotype, with complete wing and haltere reduction, female sterility, and erect postscutellar bristles. (Williams et al., 1990) Adults exhibit severely reduced wings. Margin structures are never observed and the entire wing blade appears to be deleted leaving only portions of the ventral wing hinge. Wing reduction can be suppressed by Egfr^unspecified, suppression is variable. (Simmonds et al., 1997) Wing phenotype is unaffected by temperature. (Silber et al., 1997)
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 4 )
Bloomington	999 In(2R)vg^U, wg^Sp-1 vg^U mam^U Kr^If-1/SM5 1350 In(2R)vg^U, wg^Sp-1 amos^Tft vg^U mam^U Pin²/SM1
Kyoto	106284 In(2R)vg^U, wg^Sp-1 Tft¹ vg^U mam^U Pin²/SM1 101515 In(2L)t In(2R)Cy, Roi¹ cn² bw¹ sp¹ or¹ / In(2R)vg^U, vg^U
Notes on Origin
Discoverer	Ives, 31st Dec. 1955.

Comments
	Analysis of a vg^U revertant (vg^UR2) indicates that sequences from the mam locus are required for vg^U dominance. The homozygous embryonic lethality of In(2R)vg^U may just be due to the mam^U mutation. It is also possible that homozygous vg^U dominance is lethal. No alteration in vg^U dominance is seen in combination with z^v77h, suggesting that the dominance is not produced by z- dependent transvection effects. (Williams et al., 1990)
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	vg^U
Name Synonym	Ultra
Secondary FlyBase IDs

References ( 9 )
Research paper	Silber et al., 1997, Molec. gen. Genet. 256(3): 328--332 Temperature regulates expression of the Drosophila vestigial gene only in mutant wing discs. [FBrf0099521] Simmonds et al., 1997, Mech. Dev. 67(1): 17--33 The effect of dominant vestigial alleles upon vestigial-mediated wing patterning during development of Drosophila melanogaster. [FBrf0098887] Rabinow and Birchler, 1990, Genetics 125: 41--50 Interactions of vestigial and scabrous with the Notch locus of Drosophila melanogaster. [FBrf0051947] Williams et al., 1990, Genetics 125: 833--844 Genetic and molecular analysis of vg<up>U</up> and vg<up>W</up>: two dominant vg alleles associated with gene fusions in Drosophila. [FBrf0051982] Williams and Bell, 1988, EMBO J. 7: 1355--1363 Molecular organization of the vestigial region in Drosophila melanogaster. [FBrf0047923] Bownes and Roberts, 1981, J. Embryol. exp. Morphol. 65(Suppl.): 49--76 Analysis of vestigial<up>W</up> (vg<up>W</up>) a mutation causing homoeosis of haltere to wing and posterior wing duplications in Drosophila melanogaster. [FBrf0036848] Silber and Becker, 1981, Genetica 55(3): 217--220 Hypoxanthine-guanine-phosphoribosyl-transferase (HGPRT) activity in the vestigial mutant of Drosophila melanogaster: Effect of inhibitors of the purine pathway. [FBrf0036483] Ives, 1956, D. I. S. 30: 72--73 [New mutants report.] [FBrf0063536]
Abstract	Simmonds and Bell, 1996, A. Dros. Res. Conf. 37: 295 Mechanisms leading to the creation of dominant vestigial mutations in Drosophila melanogaster. [FBrf0085938]

Allele Dmel\vgU

Allele Dmel\vg^U