FB2025_01 , released February 20, 2025
Allele: Dmel\vls3
Open Close
General Information
Symbol
Dmel\vls3
Species
D. melanogaster
Name
FlyBase ID
FBal0018015
Feature type
allele
Associated gene
Dmel\vls
Associated Insertion(s)
Carried in Construct
Also Known As
vlsPG
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Schupbach and Wieschaus, 1989, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T.

(Anne and Mechler, 2005, Cavey et al., 2005)

Amino acid replacement: R70term.

(Anne and Mechler, 2005, Cavey et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:20,065,391..20,065,391 [-]
Nucleotide change:

C20065391T

Reported nucleotide change:

C?T

Amino acid change:

R70term | vls-PA

Reported amino acid change:

R70term

(Cavey et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants have agametic gonads.

      (Marhold et al., 2003)

      Eggs derived from homozygous females form a syncytial blastoderm but 80-90% of the embryos fail to cellularise. Those that do cellularise show variable cellularisation defects. The embryos show a "grandchildless-knirps" phenotype; they lack polar granules and pole cells and show typical maternal kni-like abdominal segment deletions.

      (Schupbach and Wieschaus, 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      vls3 is a suppressor of primordial germ cell | ectopic phenotype of oskbcd.UTR

      (Anne and Mechler, 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Injection of nosN5 RNA into vls2/vls3 embryos completely rescues the abdominal phenotype.

      (Wang and Lehmann, 1991)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      vls3 is rescued by vlsTag:HA

      (Anne and Mechler, 2005)

      vls3 is rescued by vls+t2.04

      (Anne and Mechler, 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      PG65
      valoisPG
      (Jankovics et al., 2001)
      vls3
      (Anne, 2010, Gonsalvez et al., 2006)
      vlsPG65
      (Cavey et al., 2005)
      vlsPG
      (Forrest and Gavis, 2003, Wang and Lehmann, 1991, Tearle and Nusslein-Volhard, 1987)
      Name Synonyms
      Secondary FlyBase IDs
        References (13)