FB2025_01 , released February 20, 2025
Allele: Dmel\Axsr1
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General Information
Symbol
Dmel\Axsr1
Species
D. melanogaster
Name
revertant 1
FlyBase ID
FBal0033470
Feature type
allele
Associated gene
Dmel\Axs
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Whyte et al., 1993)
Mutagen
ethyl methanesulfonate
(Whyte et al., 1993)
Progenitor genotype
AxsD
(Whyte et al., 1993)
Cytology
Description

Amino acid replacement: F270term.

(Kramer and Hawley, 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:16,681,521..16,681,521 [-]
Nucleotide change:

G16681521A

Amino acid change:

W270term | Axs-PA

Reported amino acid change:

W270term

Comment:

TGG to TGA; revertant of AxsD; see GB:AF101361

(Kramer and Hawley, 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Complete loss of the dominant phenotype: less than 2% X chromosome non-disjunction. Homozygotes show no meitoic phenotype, though transheterozygotes with Axsr2 show a strong meiotic phenotype. Effect is limited to homologous achiasmate segregations. Nondisjunction is not accompanied by a significant level of chromosome loss.

      (Whyte et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Revertant.

      Comments
      Comments

      Does not suppress AxsD in transheterozygotes.

      (Whyte et al., 1993)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      AxsR1
      (Kramer and Hawley, 2003)
      Axsr1
      Name Synonyms
      revertant 1
      (Whyte et al., 1993)
      Secondary FlyBase IDs
        References (2)