FB2025_01 , released February 20, 2025
Allele: Dmel\can3
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General Information
Symbol
Dmel\can3
Species
D. melanogaster
Name
FlyBase ID
FBal0049375
Feature type
allele
Associated gene
Dmel\can
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Hiller et al., 2001)
Mutagen
ethyl methanesulfonate
(Lin et al., 1996)
Progenitor genotype
Cytology
Description

Nucleotide substitution: T2105C Amino acid replacement: S687P.

(Hiller et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:10,264,757..10,264,757 [-]
Nucleotide change:

T10264757C

Reported nucleotide change:

T2105C

Amino acid change:

S687P | can-PA

Reported amino acid change:

S687P

(Hiller et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Early stages of spermatogenesis up through mature primary spermatocytes are present and normal. Postmeiotic stages are completely absent. Mutant testes have an abundance of mature primary spermatocytes with large, round nuclei and prominent nucleoli. Spermatocytes arrest in the G2/M transition of meiosis I with partial chromosome condensation.

      (Lin et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      can3/can4 is rescued by can+t5.7

      (Hiller et al., 2001)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      can3
      (Laktionov et al., 2014, Doggett et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)