FB2025_01 , released February 20, 2025
Allele: Dmel\mtrmexc13
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General Information
Symbol
Dmel\mtrmexc13
Species
D. melanogaster
Name
FlyBase ID
FBal0151716
Feature type
allele
Associated gene
Dmel\mtrm
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Harris et al., 2003)
Progenitor genotype
P{SUPor-P}Exo70KG08051
(Harris et al., 2003)
Cytology
Description

Excision of the P{SUPor-P} element, which has resulted in a large deletion of material upstream of the site of the insertion, including the first 3 exons of exo70.

(Harris et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous females show precocious nuclear envelope breakdown in stage 12 oocytes.

      (Xiang et al., 2007)

      Heterozygosity for mtrmexc13 results in elevated X (49.0%) and fourth (29.0%) chromosome nondisjunction in In(1)FM7/X ; svspa-pol females compared to controls. The level of X chromosome nondisjunction in heterozygous mtrmexc13 females carrying two normal sequence X chromosomes is only 3.1%, while the frequency of fourth chromosome nondisjunction in these females is 31.0%.

      (Harris et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The "exc13" chromosome (which carries the exo70exc13 and mtrmexc13 alleles) shows recessive semi-lethality; less than 50% of the expected number of homozygous adults eclose out of their pupal cases and those that do die within 1-2 days of eclosion.

      (Harris et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Associated with: exo70exc13.

      (Harris et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mtrmexc13
      (Xiang et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)