FlyBase Allele Report: Dmel\Trm7-34[e02001]

General Information

Symbol

Dmel\Trm7-34^e02001

Species

D. melanogaster

Name

FlyBase ID

FBal0161086

Feature type

allele

Associated gene

Dmel\Trm7-34

Associated Insertion(s)

PBac{RB}Trm7-34^e02001

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

piggyBac activity

Nature of the Allele

Allele class

Mutagen

piggyBac activity

(Bloomington Drosophila Stock Center, 2004.11.6)

Progenitor genotype

Associated Insertion(s)

PBac{RB}Trm7-34^e02001

Cytology

Description

Allele components

Component

Use(s)

Inserted element

PBac{RB}

gene trap

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:21,133,232..21,133,232 [-]

(Bloomington Drosophila Stock Center, 2004.11.6)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of non-syndromic X-linked intellectual disability 9

CEC

(Brazane et al., 2023)

CEC with Trm7-32^K28A

(Brazane et al., 2023)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage

(Angelova et al., 2020)

abnormal locomotor behavior | adult stage

(Angelova et al., 2020)

abnormal size | adult stage (with Df(3R)ED10845)

(Angelova et al., 2020)

fertile

(Bloomington Drosophila Stock Center, 2004.11.6)

viable

(Angelova et al., 2020, Bloomington Drosophila Stock Center, 2004.11.6)

Phenotype Manifest In

ovary (with Df(3R)ED10845)

(Angelova et al., 2020)

Detailed Description

Statement

Reference

Trm7-34^e02001 homozygotes survive until adulthood under standard conditions, without major growth defects or significant developmental delays; adults are sluggish but show normal lifespan. However, they show increased viral load upon infection with Drosophila C Virus, as compared to controls.

Trm7-34^e02001/Df(3R)ED10845 transheterozygotes show small ovaries.

(Angelova et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Trm7-34^e02001 has abnormal locomotor behavior | adult stage | recessive phenotype, non-enhanceable by Trm7-32^K28A/Trm7-32^K28A

(Angelova et al., 2020)