FB2025_01 , released February 20, 2025
Allele: Dmel\brZ1.UAS
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General Information
Symbol
Dmel\brZ1.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0190116
Feature type
allele
Associated gene
Dmel\br
Associated Insertion(s)
Carried in Construct
P{UAS-br.Z1}
Also Known As
UAS-br-Z1, UAS-Broad Z1, UAS-BrZ1
Key Links
Transgenic product class
wild_type
(Schubiger et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Schubiger et al., 2005)
Mutagen
in vitro construct
(Schubiger et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-br.Z1}
Cytology
Description

UAS regulatory sequences drive expression of br-Z1 isoform coding sequences.

(Schubiger et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
br
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      prothoracic gland, with Scer\GAL4P0206

      (Zhou et al., 2004)

      sensory neuron & dorsal mesothoracic disc, with Scer\GAL4bbg-C96

      (Schubiger et al., 2005)

      wing margin & sensory neuron, with Scer\GAL4bbg-C96

      (Schubiger et al., 2005)
      Detailed Description
      Statement
      Reference

      Expression of brZ1.Scer\UAS in the wing disc under the control of Scer\GAL4C96 induces precocious sensory neuron development in approximately 97.5% of cases. In about 15% of the discs, one or two neurons differentiate in the posterior margin, which is normally devoid of sensory neurons.

      (Schubiger et al., 2005)

      Approximately 99% of animals expressing brZ1.Scer\UAS under the control of Scer\GAL4P0206 remain as first instar larvae.

      Expression of brZ1.Scer\UAS under the control of Scer\GAL4P0206 causes partial degeneration of the prothoracic gland portion of the ring gland by 24 hours after hatching and disappearance by 35 hours after hatching.

      (Zhou et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      brZ1.Scer\UAS
      brZ1.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (15)