Excision of P{EPgy2}lazaEY04417 results in an approximate 0.6kb deletion in laza (-309 to +913).
laza2 mutant eyes display aberrant phototransduction. Exposure of wild-type flies to light results in a corneal negative receptor potential, which decays to baseline after cessation of the light stimulus. The amplitude of the light response is reduced nearly 3-fold in laza2 flies. The decreased phototransduction response in laza2 flies is not age dependent.
Termination of the photoresponse is approximately 4-fold faster in laza2 flies than in wild-type. Even with wild-type flies being exposed to a lower light intensity (so the electroretinogram response amplitude is the same), the laza1 flies exhibit a 2-fold quicker speed of termination of the photoresponse compared to wild-type.
