|Feature type||allele||Associated gene||Dmel\sas-6|
|Mutagen||in vitro construct - regulatory fusion, in vitro construct - coding region fusion|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
|Phenotype Manifest In|
Unfertilized eggs laid by mothers carrying two copies of sas-6[Ubi.P.T:Avic\GFP] assemble centriole-like structures.
Approximately 3% of centrioles proceed through an extra round of template-driven replication within a single nuclear cycle in syncytial embryos expressing sas-6[Ubi.P.T:Avic\GFP], and a few centrioles undergo two extra rounds of replication. Extra centrioles are detected in mitotic third larval instar brain cells in animals expressing sas-6[Ubi.P.T:Avic\GFP]. The brain cells do not have dramatic mitotic defects, and the accumulation of extra centrioles is not due to a failure in cytokinesis. No extra centrioles are detected in the female or male germline in animals expressing sas-6[Ubi.P.T:Avic\GFP]. Expression of sas-6[Ubi.P.T:Avic\GFP] results in de novo formation of centriole-like structures in approximately 30% of unfertilised eggs (which do not normally contain centrioles).
|Phenotype Manifest In|
|NOT Enhanced by|
Almost all unfertilized eggs laid by mothers carrying one copy of sas-6[Ubi.P.T:Avic\GFP] and ana2[Ubi.C.T:Avic\GFP] contain hundreds of large structures that stain for centriole markers, recruited PCM, and nucleated asters. These centriole-like structures often appear ring-shaped, and only one structure is contained within each aster. Eggs laid by mothers carrying one copy of either ana2[Ubi.C.T:Avic\GFP] or sas-6[Ubi.P.T:Avic\GFP] together with one copy of either SAK[Ubi.P.T:Avic\GFP] or Sas-4[Ubi.P.T:Avic\GFP] exhibit at most a very small number of asters in very few eggs.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 3 )|