FB2025_01 , released February 20, 2025
Allele: Hsap\BACE1UAS.cLa
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General Information
Symbol
Hsap\BACE1UAS.cLa
Species
H. sapiens
Name
FlyBase ID
FBal0241701
Feature type
allele
Associated gene
Hsap\BACE1
Associated Insertion(s)
Carried in Construct
P{UAS-BACE1.L}
Key Links
Transgenic product class
wild_type
(Loewer et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Loewer et al., 2004)
Mutagen
in vitro construct
(Loewer et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-BACE1.L}
Cytology
Description

UAS regulatory sequences drive expression of Hsap\BACE1.

(Loewer et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\BACE1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Alzheimer's disease
      CEA
      (Wang et al., 2014)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\BACE1Scer\UAS.cLa under the control of Scer\GAL4elav.PLu leads to a significant decrease in lifespan and significant deterioration of climbing ability with age, as compared to controls.

      (Wang et al., 2014)

      Scer\GAL4elav-C155>Hsap\BACE1Scer\UAS.cLa flies show no significant difference in probability of survival compared to genetic controls. Scer\GAL4elav-C155>Hsap\BACE1Scer\UAS.cLa fly brains have similar size mushroom bodies as controls (significantly larger Kenyon cell area than is seen with expression of Hsap\BACE1Scer\UAS.cGa). Flies (2-10 and 12-20 days old) with expression of Hsap\BACE1Scer\UAS.cLa driven by Scer\GAL4elav-C155 show similar climbing ability to controls.

      (Chakraborty et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\BACE1Scer\UAS.cLa
      Hsap\BACE1UAS.cLa
      Name Synonyms
      Secondary FlyBase IDs
        References (4)