Allele Dmel\trpm¹

General Information
Symbol	Dmel\trpm¹	Species	D. melanogaster
Name		FlyBase ID	FBal0244769
Feature type	allele	Associated gene	Dmel\trpm

Allele class
Mutagen	Delta2-3
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	Delta2-3 (Hofmann et al., 2010)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{EPgy2}trpm^EY01618 (Hofmann et al., 2010)
Nature of the lesion	Statement Reference Imprecise excision of the progenitor insertion, resulting in a deletion that removes exons C9-C11 encoding amino acid residues 364 to 511. (Hofmann et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	lethal (with Df(2R)XTE-18) (Hofmann et al., 2010) lethal (with trpm²) (Hofmann et al., 2010) lethal (with trpm^EY01618) (Hofmann et al., 2010) lethal \| pupal stage \| recessive (Hofmann et al., 2010)
Phenotype Manifest In
	embryonic/larval anterior Malpighian tubule (Hofmann et al., 2010)
Detailed Description
	Statement Reference Homozygotes show pupal lethality when raised on standard food. However, if the food is supplemented with 30mM Mg[2+], homozygotes show almost complete larval lethality (this high level of Mg[2+] has no effect on the survival of control animals). Homozygous larvae raised on food containing 30mM Mg[2+] are smaller and thinner than wild type. These larvae show a dramatic decrease in protein content (mutant larvae raised on standard food show only a relatively modest, although significant, reduction in protein content compared to controls). Homozygous larvae exposed to food containing 30mM Mg[2+] for one day show a marked reduction in locomotor activity along with a reduction in foraging activity. The anterior pair of Malpighian tubules of homozygous third instar larvae are 30% shorter than wild type and contain fewer cells. The difference compared to wild type is restricted to the main segment and the lower segment, while the transitional segment, initial segment and posterior Malpighian tubules are similar in length to wild type. (Hofmann et al., 2010) Mutant third instar larvae show the same preference for 17.5[o]C over 14[o]C in a two-way choice test as do wild-type controls. (Kwon et al., 2010)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	trpm¹ (Hofmann et al., 2010, Kwon et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Hofmann et al., 2010, PLoS ONE 5(5): e10519 Drosophila TRPM channel is essential for the control of extracellular magnesium levels. [FBrf0210792] Kwon et al., 2010, J. Neurosci. 30(31): 10465--10471 Fine Thermotactic Discrimination between the Optimal and Slightly Cooler Temperatures via a TRPV Channel in Chordotonal Neurons. [FBrf0211446]

Allele Dmel\trpm1

Allele Dmel\trpm¹