FB2025_01 , released February 20, 2025
Allele: Dmel\gang-of-four2
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General Information
Symbol
Dmel\gang-of-four2
Species
D. melanogaster
Name
FlyBase ID
FBal0246077
Feature type
allele
Associated gene
gang-of-four
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous clones in the eye (induced using the eyFLP technique) overgrow relative to their wild-type neighbours, without overall hyperplasia of the eye.

        Mosaic animals in which the eyes and head cuticle are composed almost entirely of homozygous tissue (generated using the Minute technique) have significantly larger eyes than controls.

        (Beam and Moberg, 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Other
        Statement
        Reference

        gang-of-four2, pucE69/puc[+] has lethal | dominant phenotype

        (Beam and Moberg, 2010)

        gang-of-four2, pucA251.1F3/puc[+] has lethal | dominant phenotype

        (Beam and Moberg, 2010)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        gfr2 dominantly suppresses the wing notching phenotype seen in Df(1)N-54l9 heterozygotes (the penetrance of the phenotype is significantly decreased in the double heterozygotes).

        (Beam and Moberg, 2010)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        gang-of-four2
        gfr2
        (Beam and Moberg, 2010)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)