FB2025_01 , released February 20, 2025
Allele: Dmel\Map205S283A.UASp.Tag:MYC
Open Close
General Information
Symbol
Dmel\Map205S283A.UASp.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0246844
Feature type
allele
Associated gene
Dmel\Map205
Associated Insertion(s)
Carried in Construct
P{UASp-Map205.S283A.MYC}
Key Links
Transgenic product class
missense_variant
(Archambault et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Archambault et al., 2008)
Mutagen
in vitro construct
(Archambault et al., 2008)
Progenitor genotype
Carried in construct
P{UASp-Map205.S283A.MYC}
Cytology
Description

UASp regulatory sequences drive expression of a mutant form of Map205 which carries a Ser[283]-to-Ala amino acid substitution, and tagged with Tag:MYC.

(Archambault et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Map205
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos laid by mothers overexpressing Map205S283A.Scer\UAS.T:Hsap\MYC in the germ-line driven by Scer\GAL4mat.αTub67C.T:Hsim\VP16 hatch at a normal rate compared to wild-type controls.

      (Archambault et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The majority of embryos laid by mothers heterozygous for polo11 and overexpressing Map205S283A.Scer\UAS.T:Hsap\MYC in the germ-line driven by Scer\GAL4mat.αTub67C.T:Hsim\VP16 fail to hatch. These embryos display a very high percentage of mitoses in which a single centrosome is detached from the nuclear envelope in prophase. This defect is extremely rare in wild-type embryos.

      (Archambault et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Map205S283A.Scer\UAS.T:Hsap\MYC
      Map205S283A.UASp.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)