FB2025_01 , released February 20, 2025
Allele: Dmel\Ns251
Open Close
General Information
Symbol
Dmel\Ns251
Species
D. melanogaster
Name
FlyBase ID
FBal0248530
Feature type
allele
Associated gene
Dmel\Ns2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Matsuo et al., 2010)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q14term.

(Matsuo et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:17,568,289..17,568,289 [-]
Nucleotide change:

C17568289T

Amino acid change:

Q14term | Ns2-PA

Reported amino acid change:

Q14term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Matsuo et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones are not recovered in the wing disc.

      Expression of ns2NIG.6501R under the control of Scer\GAL4ey.PH in the presence of ns251 results in a rough eye phenotype.

      (Matsuo et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Ns211

      (Matsuo et al., 2010)
      Rescued by

      Ns251 is rescued by Ns2UAS.cMa/Scer\GAL4αTub84B.PL

      (Matsuo et al., 2010)
      Comments

      Expression of ns2Scer\UAS.cMa under the control of Scer\GAL4αTub84B.PL rescues the lethality of ns251 homozygotes.

      (Matsuo et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ns251
      ns251
      (Matsuo et al., 2011, Matsuo et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)