FB2025_01 , released February 20, 2025
Allele: Dmel\Keap1EY1
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General Information
Symbol
Dmel\Keap1EY1
Species
D. melanogaster
Name
FlyBase ID
FBal0248712
Feature type
allele
Associated gene
Dmel\Keap1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Male Keap1EY1/+ flies show significantly increased survival rates after exposure to oxidative stress. Importantly, male Keap1EY1 heterozygotes also live significantly longer than their otherwise genetically identical siblings. Female Keap1EY1 heterozygotes do not show significant differences in either oxidative stress resistance or longevity.

        (Sykiotis and Bohmann, 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        Keap1EY1/Keap1[+] is a suppressor of short lived phenotype of Pink1RNAi.UAS.cYa, Scer\GAL4Mhc.PW

        (Imai et al., 2010)
        NOT Suppressor of
        Statement
        Reference

        Keap1EY1/Keap1[+] is a non-suppressor of visible phenotype of Pink1RNAi.UAS.cYa, Scer\GAL4Mhc.PW

        (Imai et al., 2010)
        Phenotype Manifest In
        NOT Suppressor of
        Statement
        Reference

        Keap1EY1/Keap1[+] is a non-suppressor of wing phenotype of Pink1RNAi.UAS.cYa, Scer\GAL4Mhc.PW

        (Imai et al., 2010)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The abnormal wing posture caused by expression of Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW is not suppressed Keap1EY1/+, but the viability of aged flies expressing Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW is increased by Keap1EY1/+.

        (Imai et al., 2010)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Keap1EY1
        keap1EY1
        (Imai et al., 2010, Sykiotis and Bohmann, 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)