Young flies (up to 22 days after eclosion) expressing Hsap\APP^{Aβ42.Scer\UAS.att} under the control of Scer\GAL4^elav-C155 exhibit robust circadian rhythmicity in constant darkness (DD) that is essentially identical to that observed in control flies. A subpopulation of flies develop arrhythmic behavior by the 32 days after eclosion. Overall locomotor activity is unaffected. Locomotor rhythm in DD is comparable to controls when Hsap\APP^{Aβ42.Scer\UAS.att} is expressed under the control of Scer\GAL4^tim.PE or Scer\GAL4^P2.4.Pdf.

Expression of a single copy of Hsap\APP^{Aβ42.Scer\UAS.att} is found not to result in significant locomotor or survival defects.

Flies expressing two copies of Hsap\APP^{Aβ42.Scer\UAS.att} under the control of Scer\GAL4^elav-C155 have a much shorter lifespan with a median survival (50% flies still alive) of 23 vs. 63 days in control flies. Mortality in the mutant flies begins to increase beyond day 20.

Flies expressing either one or two copies of Hsap\APP^{Aβ42.Scer\UAS.att} under the control of Scer\GAL4^GMR.PF do not accumulate significant quantities of SDS-insoluble deposits in the head.

Flies expressing two copies of Hsap\APP^{Aβ42.Scer\UAS.att} under the control of Scer\GAL4^GMR.PF have wild-type eyes.

Flies expressing two copies of Hsap\APP^{Aβ42.Scer\UAS.att} under the control of Scer\GAL4^elav-C155 have a significantly shorter lifespan than wild-type controls.