Allele Hsap\APP^{Aβ42.Scer\UAS.att}

General Information
Symbol	Hsap\APP^{Aβ42.Scer\UAS.att}	Species	H. sapiens
Name		FlyBase ID	FBal0276876
Feature type	allele	Associated gene	Hsap\APP

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Speretta et al., 2012)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of a single copy of the 42 amino acid residue form of Aβ (amyloid β). (Speretta et al., 2012)
Carried in construct	M{UAS-Aβ42.att} (Speretta et al., 2012, Berg et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	short lived, with Scer\GAL4^elav-C155 (Speretta et al., 2012, Berg et al., 2009)
Phenotype Manifest In

Detailed Description
	Statement Reference Flies expressing either one or two copies of Hsap\APP[Aβ42.Scer\UAS.att] under the control of Scer\GAL4[GMR.PF] do not accumulate significant quantities of SDS-insoluble deposits in the head. Flies expressing two copies of Hsap\APP[Aβ42.Scer\UAS.att] under the control of Scer\GAL4[GMR.PF] have wild-type eyes. Flies expressing two copies of Hsap\APP[Aβ42.Scer\UAS.att] under the control of Scer\GAL4[elav-C155] have a significantly shorter lifespan than wild-type controls. (Speretta et al., 2012) Scer\GAL4[elav-C155]-mediated expression of Hsap\APP[Aβ42.Scer\UAS.att] reduces median lifespan to 20 days, compared to 32 days in controls. (Berg et al., 2009)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Hsap\APP^{Aβ42.Scer\UAS.att}
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Speretta et al., 2012, J. Biol. Chem. 287(24): 20748--20754 Expression in Drosophila of Tandem Amyloid β Peptides Provides Insights into Links between Aggregation and Neurotoxicity. [FBrf0218555] Berg et al., 2009, Neurodegener. Dis. 6(3): 127--138 Modeling familial amyloidotic polyneuropathy (Transthyretin V30M) in Drosophila melanogaster. [FBrf0207975]

Allele Hsap\APPAβ42.Scer\UAS.att

Allele Hsap\APP^{Aβ42.Scer\UAS.att}