FB2025_01 , released February 20, 2025
Allele: Dmel\Ccdc56D6
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General Information
Symbol
Dmel\Ccdc56D6
Species
D. melanogaster
Name
FlyBase ID
FBal0277036
Feature type
allele
Associated gene
Dmel\Ccdc56
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Peralta et al., 2012)
Mutagen
P-element activity
(Peralta et al., 2012)
Progenitor genotype
P{SUPor-P}CG11658KG07792
(Peralta et al., 2012)
Cytology
Description

Excision of the P{SUPor-P} element from P{SUPor-P}KG07792 results in a 570bp deletion that includes the Ccdc56 initiation codon and the first 23 nucleotides of the open reading frame.

(Peralta et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:11,708,537..11,709,106 [+]
Comment:

570 bp deletion resulting from the imprecise excision of P{SUPor-P}CG11658KG07792, which includes the first 23 bp of the Ccdc56 ORF.

(Peralta et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Analysis of mouth hook morphology shows that homozygous Ccdc56D6 mutants take 10-12 days to reach the third instar larval stage, compared to 4-5 days in controls. The resulting third instar larvae are smaller than controls, remain at this stage for over 20 days, and die before pupariation.

      (Peralta et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      Ccdc56D6 has lethal | recessive | third instar larval stage phenotype, non-suppressible by Scer\GAL4arm.PU

      (Peralta et al., 2012)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of mtTFB1Scer\UAS.P\T.cPa under the control of Scer\GAL4arm.PU fails to suppress the larval lethality seen in Ccdc56D6.

      (Peralta et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Ccdc56D11

      (Peralta et al., 2012)
      Comments

      Ccdc56D6 fails to complement the lethality seen in Ccdc56D11.

      (Peralta et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ccdc56D6
      ccdc56D6
      (Peralta et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)