FB2025_01 , released February 20, 2025
Allele: Dmel\Spn88EaRNAi.UASp
Open Close
General Information
Symbol
Dmel\Spn88EaRNAi.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0280241
Feature type
allele
Associated gene
Dmel\Spn88Ea
Associated Insertion(s)
Carried in Construct
P{UASp-Spn88Ea.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Charron et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Charron et al., 2008)
Mutagen
in vitro construct
(Charron et al., 2008)
Progenitor genotype
Carried in construct
P{UASp-Spn88Ea.RNAi}
Cytology
Description

UASp regulatory sequences drive expression of two copies of a ~0.9kb Spn88Ea fragment in an inverted repeat arrangement and separated with an intron.

(Charron et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Spn88Ea
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      No visible phenotypes are seen in flies expressing Spn88EadsRNA.Scer\UAS.P\T under the control of Scer\GAL4Act5C.PI.

      Flies expressing Spn88EadsRNA.Scer\UAS.P\T under the control of Scer\GAL4da.G32 eclose normally, but exhibit defects in the unfolding and expansion of their wings. The wings remain folded and hypotrophic throughout the adult life of the flies. Lifespan is also severely compromised, with all flies having died by 5 days after eclosion. Shortly after eclosion the unopened wings appear similar in size and shape to those of wild type flies. All veins, bristles and hairs appear to be present and normal.

      (Charron et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Spn88EaRNAi.UASp
      Spn88EadsRNA.Scer\UAS.P\T
      Spn88EadsRNA.UASp
      Name Synonyms
      Secondary FlyBase IDs
        References (2)