FB2025_01 , released February 20, 2025
Allele: Dmel\sicilyC
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General Information
Symbol
Dmel\sicilyC
Species
D. melanogaster
Name
FlyBase ID
FBal0284112
Feature type
allele
Associated gene
Dmel\sicily
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Yamamoto et al., 2013-, Zhang et al., 2013)
Progenitor genotype
Cytology
Description

Deletion removing the promoter and first two exons of sicily.

(Zhang et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Leigh disease
      CEA
      (Zhang et al., 2013)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      sicilyC clones in mosaic early third instar larval fat bodies do not show defects in cell size compared to controls; these cells do not accumulate autophagosome-like structures (Atg8a-positive), as compared to controls.

      (Liu et al., 2018)

      Mutant flies containing homozygous eyes (generated using the eyFLP method) show degenerative electroretinogram defects which worsen with age. The amplitude of the ERG is reduced in 1 day old flies and is almost completely abolished after 24 days.

      (Zhang et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      sicilyEY02706

      (Zhang et al., 2013)
      Rescued by

      sicilyC is rescued by Scer\GAL4da.G32/sicilyUAS.cZa

      (Zhang et al., 2013)

      sicilyC is rescued by sicilymCherry

      (Zhang et al., 2013)
      Comments

      sicilyT:Disc\RFP-mCherry rescues the lethality and electroretinogram defects of sicilyC.

      (Zhang et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      XE07C
      (Zhang et al., 2013)
      sicilyC
      (Yamamoto et al., 2013-)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)